1: CH2Cl2 / 24 h / Heating 2: 80 percent / aq. LiOH / methanol / 12 h / 45 °C 3: 34 percent / DDQ / dioxane / 0.08 h / Ambient temperature 4: 33 percent / Et3N, ClCOOEt / tetrahydrofuran / 0.08 h / 0 °C 5: 81 percent / Amberlyst 15 / methanol / 1 h / 45 °C View Scheme

1: 34 percent / DDQ / dioxane / 0.08 h / Ambient temperature 2: 33 percent / Et3N, ClCOOEt / tetrahydrofuran / 0.08 h / 0 °C 3: 81 percent / Amberlyst 15 / methanol / 1 h / 45 °C View Scheme

1: 89 percent / DIBAL-H / toluene; hexane / 0.5 h / -78 °C 2: Et3N, SO3-C5H5N, DMSO / Ambient temperature 3: CH2Cl2 / 24 h / Heating 4: 80 percent / aq. LiOH / methanol / 12 h / 45 °C 5: 34 percent / DDQ / dioxane / 0.08 h / Ambient temperature 6: 33 percent / Et3N, ClCOOEt / tetrahydrofuran / 0.08 h / 0 °C 7: 81 percent / Amberlyst 15 / methanol / 1 h / 45 °C View Scheme

1: 80 percent / (n-Bu)4NF / tetrahydrofuran / 4 h / 40 °C 2: Et3N, SO3-C5H5N, DMSO / Ambient temperature 3: CH2Cl2 / 6 h / Heating 4: 76 percent / DIBAL-H / toluene; hexane / 0.5 h / -78 °C 5: Et3N, SO3-C5H5N, DMSO / Ambient temperature 6: CH2Cl2 / 24 h / Heating 7: aq. LiOH / methanol / 12 h / 45 °C 8: 88 percent / DDQ / dioxane / 0.08 h / Ambient temperature 9: Et3N, ClCOOEt / tetrahydrofuran / 0.08 h / 0 °C 10: Amberlyst 15 / methanol / 1 h / 45 °C View Scheme

1: 80 percent / aq. LiOH / methanol / 12 h / 45 °C 2: 34 percent / DDQ / dioxane / 0.08 h / Ambient temperature 3: 33 percent / Et3N, ClCOOEt / tetrahydrofuran / 0.08 h / 0 °C 4: 81 percent / Amberlyst 15 / methanol / 1 h / 45 °C View Scheme

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; InI / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide / 0 - 22 °C / |Inert atmosphere 2.1: trifluoroacetic acid / 48 h / |Inert atmosphere 3.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 3.2: 6.5 h / -78 - 0 °C / |Inert atmosphere 4.1: (Ipc)2BH / tetrahydrofuran / 0 °C / |Glovebox; |Inert atmosphere 4.2: 2 h / 0 °C / |Glovebox; |Inert atmosphere 4.3: 0 - 25 °C / |Glovebox; |Inert atmosphere 5.1: lithium hydroxide hydrate; water / methanol / 24 h / 45 °C / |Inert atmosphere 6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 0.17 h / 0 °C 7.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 2 h / 0 °C / |Inert atmosphere 7.2: 2.5 h / 0 - 25 °C / |Inert atmosphere 8.1: cesium fluoride; methanol / 3 h / 25 °C / |Inert atmosphere View Scheme

1.1: trifluoroacetic acid / 48 h / |Inert atmosphere 2.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 2.2: 6.5 h / -78 - 0 °C / |Inert atmosphere 3.1: (Ipc)2BH / tetrahydrofuran / 0 °C / |Glovebox; |Inert atmosphere 3.2: 2 h / 0 °C / |Glovebox; |Inert atmosphere 3.3: 0 - 25 °C / |Glovebox; |Inert atmosphere 4.1: lithium hydroxide hydrate; water / methanol / 24 h / 45 °C / |Inert atmosphere 5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 0.17 h / 0 °C 6.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 2 h / 0 °C / |Inert atmosphere 6.2: 2.5 h / 0 - 25 °C / |Inert atmosphere 7.1: cesium fluoride; methanol / 3 h / 25 °C / |Inert atmosphere View Scheme

1.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: 6.5 h / -78 - 0 °C / |Inert atmosphere 2.1: (Ipc)2BH / tetrahydrofuran / 0 °C / |Glovebox; |Inert atmosphere 2.2: 2 h / 0 °C / |Glovebox; |Inert atmosphere 2.3: 0 - 25 °C / |Glovebox; |Inert atmosphere 3.1: lithium hydroxide hydrate; water / methanol / 24 h / 45 °C / |Inert atmosphere 4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 0.17 h / 0 °C 5.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 2 h / 0 °C / |Inert atmosphere 5.2: 2.5 h / 0 - 25 °C / |Inert atmosphere 6.1: cesium fluoride; methanol / 3 h / 25 °C / |Inert atmosphere View Scheme

1.1: (Ipc)2BH / tetrahydrofuran / 0 °C / |Glovebox; |Inert atmosphere 1.2: 2 h / 0 °C / |Glovebox; |Inert atmosphere 1.3: 0 - 25 °C / |Glovebox; |Inert atmosphere 2.1: lithium hydroxide hydrate; water / methanol / 24 h / 45 °C / |Inert atmosphere 3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 0.17 h / 0 °C 4.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 2 h / 0 °C / |Inert atmosphere 4.2: 2.5 h / 0 - 25 °C / |Inert atmosphere 5.1: cesium fluoride; methanol / 3 h / 25 °C / |Inert atmosphere View Scheme

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 0.17 h / 0 °C 2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 2 h / 0 °C / |Inert atmosphere 2.2: 2.5 h / 0 - 25 °C / |Inert atmosphere 3.1: cesium fluoride; methanol / 3 h / 25 °C / |Inert atmosphere View Scheme