1-(2,4-二氯l苯基)-2-(1H-1,2,4-噻唑-1-基)-乙酮合成路线 （共 25 条）
反应条件
1: 30 percent / TsOH / benzene / 3.5 h / Heating
2: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
3: 82 percent / dimethylformamide / 4 h / 100 °C
4: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
5: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: 72 percent / MeONa / methanol / 0.5 h / Heating
2: 30 percent / TsOH / benzene / 3.5 h / Heating
3: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
4: 82 percent / dimethylformamide / 4 h / 100 °C
5: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
6: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
2: 82 percent / dimethylformamide / 4 h / 100 °C
3: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
4: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: 82 percent / dimethylformamide / 4 h / 100 °C
2: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
3: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
2: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: 1) NaH / 1) DMF, 0 deg C, 15 min, 2) MeOH, 0 deg C, 30 min
2: conc.H2SO4 / methanol / Ambient temperature
3: 72 percent / MeONa / methanol / 0.5 h / Heating
4: 30 percent / TsOH / benzene / 3.5 h / Heating
5: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
6: 82 percent / dimethylformamide / 4 h / 100 °C
7: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
8: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: acetonitrile / 80 - 85 °C
2: 2 percent / conc. H2SO4, NaNO2 / H2O / 0 - 20 °C
View Scheme
参考文献
Krimer, M. Z.; Tashi, B. P.; Roitburd, G. V.; Shtirkov, I. M.; Manaev, S. A.; et al.
Doklady Chemistry, 1989 , vol. 308, # 4-6 p. 299 - 301
Dokl. Akad. Nauk SSSR Ser. Khim., 1989 , vol. 308, # 5 p. 1155 - 1158
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 20 °C
2: potassium carbonate / acetonitrile / 20 - 80 °C
View Scheme
参考文献
Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366
反应条件
hydrogenchloride; sodium nitrite
1.) i-PrOH; Multistep reaction;
参考文献
Kolczewski, Sabine; Adam, Geo; Stadler, Heinz; Mutel, Vincent; Wichmann, Juergen; Woltering, Thomas
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2173 - 2176
反应条件
in para-xylene
0.333333 h; Heating; Product distribution; Further Variations:Temperatures;
参考文献
Herrero, M. Antonia; Kremsner, Jennifer M.; Kappe, C. Oliver
Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 36 - 47
