1-苯基-2-(1H-1,2,4-噻唑-1-基)乙酮合成路线 (共 8 条)
反应条件
bromine; sodium acetate; acetic acid T=20°C;
参考文献
Chen, Sheng-Qin; Zhang, Yi-Chao; Liu, Fang-Ming
Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 2 p. 319 - 325
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Zeng, Yong-Ming; Chen, Sheng-Qin; Liu, Fang-Ming
Journal of Chemical Crystallography, 2012 , vol. 42, # 1 p. 24 - 28
反应条件
triethylamine in acetone
8 h; Heating;
参考文献
Abdel-Megid, Mohamed; Elnagdi, Mohamed H.; Negm, Abdalla M.
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 105 - 108
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=0 - 20°C; Alkylation;
参考文献
Bulger, Paul G.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf-H.
Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1297 - 1301
反应条件
potassium carbonate in acetonitrile
T=85°C; 0.833333 h; microwave irradiation;
参考文献
Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483
反应条件
hydrogenchloride; sodium nitrite
T=0 - 20°C;
参考文献
Astleford, Bret A.; Goe, Gerald L.; Keay, James G.; Scriven, Eric F. V.
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 731 - 732
反应条件
potassium carbonate in water
参考文献
Vlahakis, Jason Z.; Lazar, Carmen; Crandall, Ian E.; Szarek, Walter A.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 6184 - 6196
反应条件
2-chloro-acetophenone
T=180°C; 7 h;
参考文献
Smith, Keith; Small, Andrew; Hutchings, Michael G.
Chemistry Letters, 1990 , # 3 p. 347 - 350
反应条件
1: bromine / diethyl ether
2: triethylamine / acetone
View Scheme
参考文献
Chen, Sheng-Qin; Zhang, Yi-Chao; Liu, Fang-Ming
Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 2 p. 319 - 325