1-(4-氯-苯基)-2-[1,2,4]噻唑-1-基-丙烷-1-酮合成路线 （共 2 条）
反应条件
1: 1H-1,2,4-triazol With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20 - 30°C; 1.5 h; Cooling with ice-bath;
2: 2-bromo-1-(4-chlorophenyl)-1-propanone in DMF (N,N-dimethyl-formamide)
T=20 - 30°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/11410 A1, 2004 ;
Location in patent: Page 125 ;
WO 2004/011410 A1
参考文献
Pfizer Inc.
Patent: US4992454 A1, 1991 ;
