(6R-反式)-7-氨基-8-氧代-3-[[(1,2,5,6-四氢-2-甲基-5,6-二氧代-1,2,4-三嗪-3-基)硫代]甲基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸合成路线 （共 3 条）
反应条件
1: (6R,7R)-7-amino-[3-[[2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl]thio]-methyl]-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid With N,O-bis-(trimethylsilyl)-acetamide in dichloromethane T=20°C; 2 h; 2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate in dichloromethane T=20°C; 4 h; 3: With sodium hydroxide in dichloromethane; water T=15 - 20°C; pH=7.5 - 7.8;
参考文献
ACS DOBFAR S.p.A.
Patent: US2004/2601 A1, 2004 ;
Location in patent: Page 2 ;
反应条件
1: With triethylamine in methanol T=-2 - 3°C; 2: With sodium 2-ethyl hexanoate in water; isopropyl alcohol T=26 - 30°C; 2 h; Product distribution / selectivity;
参考文献
NECTAR LIFESCIENCES LTD.; SAHOO, Prabhat, Kumar; SUNDARAVADIVELAN, Sivakumaran; GAUTAM, Prashant; SHARMA, Awadhesh
Patent: WO2011/12965 A1, 2011 ;
Location in patent: Page/Page column 9; 10 ;
反应条件
1: With sodium 2-ethylhexanoate in tetrahydrofuran; water T=0 - 5°C; 2: in tetrahydrofuran; water T=5°C; pH=2.5 - 3.0;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: WO2008/41100 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;
