苄氧羰基-甘氨酰-脯氨酰-丙氨酸合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol
0.5 h;
参考文献
Dietzgen, Ralf G.; Sander, Evamarie; Christner, Juergen; Jung, Guenther
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 4 p. 441 - 453
反应条件
1: 50 percent / dimethylformamide / 17 h / Ambient temperature
2: 79 percent / 1M NaOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Kasafirek, Evzen; Sturc, Antonin; Roubalova, Alena
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 1 p. 179 - 187
反应条件
1: 1.) isobutylchloroformate, N-methylmorpholine, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 15 min, 2.) -10 deg C, 30 min
2: 93 percent / CF3COOH / CH2Cl2 / 0.25 h
3: 1.) DCC, 1-hydroxybenzotriazole / 1.) DMF, 0 deg C, 15 min, 2.) DMF, CH2Cl2, 0 deg C, 90 min; room temp., 5 h
4: 82 percent / 0.5 N NaOH / methanol / 0.5 h
View Scheme
参考文献
Dietzgen, Ralf G.; Sander, Evamarie; Christner, Juergen; Jung, Guenther
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 4 p. 441 - 453
反应条件
1: 1.) DCC, 1-hydroxybenzotriazole / 1.) DMF, 0 deg C, 15 min, 2.) DMF, CH2Cl2, 0 deg C, 90 min; room temp., 5 h
2: 82 percent / 0.5 N NaOH / methanol / 0.5 h
View Scheme
参考文献
Dietzgen, Ralf G.; Sander, Evamarie; Christner, Juergen; Jung, Guenther
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 4 p. 441 - 453
反应条件
1: 93 percent / CF3COOH / CH2Cl2 / 0.25 h
2: 1.) DCC, 1-hydroxybenzotriazole / 1.) DMF, 0 deg C, 15 min, 2.) DMF, CH2Cl2, 0 deg C, 90 min; room temp., 5 h
3: 82 percent / 0.5 N NaOH / methanol / 0.5 h
View Scheme
参考文献
Dietzgen, Ralf G.; Sander, Evamarie; Christner, Juergen; Jung, Guenther
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 4 p. 441 - 453
