(R)-γ-Methyl-γ-butyrolactone合成路线 （共 67 条）
反应条件
sodium hydroxide; disodium hydrogenphosphate; porcine pancreating lipase in diethyl ether; hexane T=20°C; pH=7.2; 216 h;
参考文献
Tetrahedron Letters, , vol. 43, # 35 p. 6267 - 6270
反应条件
2,2'-azo-bisisobutyronitrile; (S,R)-Me2NCH(Me)-ferrocenyl-SeBr; triphenylstannane; triethylamine 1) THF, -78 deg C, 1 h, r.t., 20 h, 2) toluene; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 22 p. 2321 - 2322
反应条件
1: With porcine pancreatic lipase in diethyl ether T=30°C; 39 h; 2: With tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) in toluene 2 h; Heating;
参考文献
Synthetic Communications, , vol. 34, # 5 p. 817 - 828
反应条件
1.1: 47 percent Spectr. / Pseudomonas cepacia lipase / toluene / 24 h / 70 °C 2.1: LiOH / methanol / 12 h / 20 °C 2.2: HCl / methanol; H2O / 72 h / 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 7 p. 2582 - 2587
反应条件
1: 70 percent / pyridine / CHCl3 / 2.5 h / Ambient temperature 2: 1.) ZnCl2, NaBH4, 2.) 1M LiOH / 1.) THF, 2.) THF, room temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 44 p. 15061 - 15068
反应条件
hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 19 p. 2513 - 2516
反应条件
hydrogen; triethylamine; palladium on activated charcoal
参考文献
Tetrahedron Letters, , vol. 25, # 52 p. 6041 - 6044
反应条件
1.1: 77 percent / MCPBA / CH2Cl2 / 17 h 2.1: ethanol / 20 °C 3.1: aq. KOH / 4 h / Heating 4.1: 0.94 g / dimethylformamide / 24 h / 20 °C 5.1: porcine pancreatic lipase / diethyl ether / 39 h / 30 °C 5.2: tributyltin hydride; 1,1'-azobis(cyclohexanecarbonitrile) / toluene / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 34, # 5 p. 817 - 828
反应条件
1.1: ethanol / 20 °C 2.1: aq. KOH / 4 h / Heating 3.1: 0.94 g / dimethylformamide / 24 h / 20 °C 4.1: porcine pancreatic lipase / diethyl ether / 39 h / 30 °C 4.2: tributyltin hydride; 1,1'-azobis(cyclohexanecarbonitrile) / toluene / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 34, # 5 p. 817 - 828
反应条件
1: hydrogen bromide 2: H2, triethylamine / Pd(C) View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 52 p. 6041 - 6044
