sodium hydroxide in water 0.5 h; Ambient temperature;

1: With triphenylphosphine in tetrahydrofuran 2: With ammonia in tetrahydrofuran

1.1: potassium carbonate; trifluoromethanesulfonyl azide / dichloromethane; water; methanol 2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C 2.2: pH 2.5 / Cooling with ice 3.1: N-ethyl-N,N-diisopropylamine; pyridine / 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C 4.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere 5.1: triphenylphosphine / tetrahydrofuran View Scheme

1.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C 1.2: pH 2.5 / Cooling with ice 2.1: N-ethyl-N,N-diisopropylamine; pyridine / 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C 3.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere 4.1: triphenylphosphine / tetrahydrofuran View Scheme

1: N-ethyl-N,N-diisopropylamine; pyridine / 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C 2: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere 3: triphenylphosphine / tetrahydrofuran View Scheme

1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere 2: triphenylphosphine / tetrahydrofuran View Scheme

1: silver trifluoromethanesulphonate / tetrahydrofuran; diethyl ether / 3.5 h / -3 °C 2: 71.5 percent / 0.1 M aq. NaOH / CH2Cl2; methanol / 0.33 h / 0 °C 3: 0.1 M NaOH / H2O / 0.5 h / Ambient temperature View Scheme

1: silver trifluoromethanesulphonate / tetrahydrofuran; diethyl ether / 3.5 h / -3 °C 2: 71.5 percent / 0.1 M aq. NaOH / CH2Cl2; methanol / 0.33 h / 0 °C 3: 0.1 M NaOH / H2O / 0.5 h / Ambient temperature View Scheme

1: HCl / CH2Cl2 / 0.17 h / Ambient temperature 2: silver trifluoromethanesulphonate / tetrahydrofuran; diethyl ether / 3.5 h / -3 °C 3: 71.5 percent / 0.1 M aq. NaOH / CH2Cl2; methanol / 0.33 h / 0 °C 4: 0.1 M NaOH / H2O / 0.5 h / Ambient temperature View Scheme

1: 71.5 percent / 0.1 M aq. NaOH / CH2Cl2; methanol / 0.33 h / 0 °C 2: 0.1 M NaOH / H2O / 0.5 h / Ambient temperature View Scheme