(S)-N-Boc-3,5-二溴-4-羟基-苯丙氨酸合成路线 （共 5 条）
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 24 h;
参考文献
Ding, Wenfeng; Zhang, Jiali; Yao, Zhi; Lu, Rong; Wu, Dezhu; Li, Ginfu; Shen, Zilong; Sun, Yingji; Lin, Gang; Wang, Chao; Zhao, Ming; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4989 - 4994
反应条件
1: 57 percent / 1.) Br2 / acetic acid; H2O / 1.) r.t., 90 min; 75 deg C, 20 min 2: 1.) NaNO2, 2 N HBr; 2.) ion-exchange resin Dowex 50 W-8 / 1.) Sandmeyer catalyst / 1.) water, 40 deg C, 30 min 3: 5.3 percent / 1 N NaOH / 2-methyl-propan-2-ol; H2O / 24 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 66, # 3 p. 960 - 970
反应条件
1: 1.) NaNO2, 2 N HBr; 2.) ion-exchange resin Dowex 50 W-8 / 1.) Sandmeyer catalyst / 1.) water, 40 deg C, 30 min 2: 5.3 percent / 1 N NaOH / 2-methyl-propan-2-ol; H2O / 24 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 66, # 3 p. 960 - 970
反应条件
sodium hydroxide in water; tert-butyl alcohol 24 h; Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 66, # 3 p. 960 - 970
反应条件
1: 69.4 percent / bromine / acetic acid / 2 h / 50 - 60 °C 2: 85.2 percent / NaOH / H2O; tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 18 p. 4989 - 4994
