3-(3-呋喃)-2-丙酸乙酯合成路线 （共 7 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=70°C; Inert atmosphere;
参考文献
Meng, Lingkui; Kamada, Yuko; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10048 - 10051
Angew. Chem., 2013 , vol. 125, # 38 p. 10232 - 10235,4
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 6 h;
参考文献
ASTRAZENECA AB
Patent: US2008/4302 A1, 2008 ;
Location in patent: Page/Page column 111 ;
US 20080004302 A1
反应条件
1: 78 percent / H2 / 5percent Pd/CaCO3 / methanol / 8 h 2: DIBAH / toluene / 4 h / -70 °C 3: 1.) n-BuLi / 1.) THF, hexane, -30 deg C, 45 min, 2.) THF, -30 to -10 deg C, 90 min View Scheme
参考文献
Liebigs Annalen, , # 10 p. 1849 - 1854
反应条件
potassium hydroxide
4 h; Heating;
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
hydrogen; Lindlar's catalyst in methanol
1.5 h;
参考文献
Davis, Christopher J.; Hurst, Timothy E.; Jacob, Aouregan M.; Moody, Christopher J.
Journal of Organic Chemistry, 2005 , vol. 70, # 11 p. 4414 - 4422
反应条件
1: 79 percent / H2 / Pd/CaCO3 / methanol / 1.5 h
2: 68 percent / diisobutylaluminium hydride / CH2Cl2; diethyl ether / 0.75 h / -70 °C
View Scheme
参考文献
Bando, Toshikazu; Shishido, Kozo
Chemical Communications, 1996 , # 11 p. 1357 - 1358
反应条件
1: 92 percent / DIBAL-H / tetrahydrofuran; CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 23 deg C, 3 h
2: 85 percent / MnO2 / CHCl3 / 20 h / Heating
View Scheme
参考文献
Parsons; Berk; Kuehne
Journal of Organic Chemistry, 1993 , vol. 58, # 26 p. 7482 - 7489
