4-氯-4'-甲氧基联苯合成路线 （共 62 条）
反应条件
1: With Argogel; tributylphosphine; azodicarboxylic acid bis[dimethylamide] in benzene
Substitution; coupling to resin; 16 h;
2: With N-chloro-succinimide in tetrahydrofuran
T=70°C; Chlorination; degermylation; 16 h; Further stages.;
参考文献
Spivey, Alan C.; Diaper, Christopher M.; Adams, Harry; Rudge, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5253 - 5263
反应条件
boron trifluoride diethyl etherate; palladium diacetate in methanol
T=20°C; 3 h;
参考文献
Saeki, Tomoyuki; Son, Eun-Cheol; Tamao, Kohei
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 9 p. 1654 - 1658
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; cesium fluoride in toluene
T=120°C; Suzuki-Miyaura coupling; 10 h; Inert atmosphere;
参考文献
Zhang, Liang; Wu, Jie
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 14-15 p. 2409 - 2413
反应条件
1: 75 percent / various solvent(s) / Heating
2: 69 percent / LiAlH4 / diethyl ether
3: 86 percent / iodine / 5 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Tada, Shin-ichi; Kunimoto, Katsutoshi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 1006 - 1010
反应条件
1: 63 percent / PCl3 / CHCl3 / 4 h / Heating
2: 75 percent / various solvent(s) / Heating
3: 69 percent / LiAlH4 / diethyl ether
4: 86 percent / iodine / 5 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Tada, Shin-ichi; Kunimoto, Katsutoshi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 1006 - 1010
反应条件
1: 88 percent / Heating
2: 63 percent / PCl3 / CHCl3 / 4 h / Heating
3: 75 percent / various solvent(s) / Heating
4: 69 percent / LiAlH4 / diethyl ether
5: 86 percent / iodine / 5 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Tada, Shin-ichi; Kunimoto, Katsutoshi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 1006 - 1010
反应条件
1: 69 percent / LiAlH4 / diethyl ether
2: 86 percent / iodine / 5 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Tada, Shin-ichi; Kunimoto, Katsutoshi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 1006 - 1010
反应条件
1.1: Te / tetrahydrofuran / 2 h / 20 °C
1.2: 80 percent / tetrahydrofuran / -20 - 20 °C
2.1: 75 percent / Pd(PPh3)4; Ag2O; Et3N / methanol / 1.5 h / Heating
View Scheme
参考文献
Cella, Rodrigo; Cunha, Rodrigo L. O. R.; Reis, Ana E. S.; Pimenta, Daniel C.; Klitzke, Clecio F.; Stefani, Helio A.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 244 - 250
反应条件
palladium; triphenylphosphine in tetrahydrofuran
T=70°C; Negishi Coupling; 24 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
反应条件
potassium acetate; 18-crown-6 ether
1.5 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Beadle, James R.; Korzeniowsky, Stephen H.; Rosenberg, David E.; Garcia-Slanga, Blanche J.; Gokel, George W.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1594 - 1603
