丙氨酰-甘氨酰-半胱氨酰-赖氨酰-天冬氨酰胺酰-苯丙氨酰-苯丙氨酰-D-色氨酰-赖氨酰-苏氨酰-苯丙氨酰-苏氨酰-丝氨酰-半胱氨酰合成路线 (共 1 条)
反应条件
1: C16H22NO4PolS With 3-methyl-phenol; trifluoroacetic acid
0.25 h; Automated synthesizersolid phase reaction;
2: N-tert-butoxycarbonyl-O-benzyl-L-serine With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide
1 h; Automated synthesizersolid phase reaction;
3: BOC-glycine; N-tert-butoxycarbonyl-L-alanine; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-L-threonine benzyl ether; BOC-S-4-methoxybenzyl-L-cysteine; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-L-lysine; N-BOC-D-tryptophan; Boc-Asn(Xan)-OH Further stages;
参考文献
Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E.; Reubi, Jean Claude
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 5981 - 5987