(R)-(-)-2-(4-甲氧基苯基)-1-甲基乙胺合成路线 （共 17 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=40°C; 24 h;
参考文献
Lu, Chuanjun; Zhou, Qi; Yan, Jun; Du, Zhiyun; Huang, Ling; Li, Xingshu
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 745 - 753
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; ω-transaminase ATA-117; pyridoxal 5'-phosphate; β-NADP+; lactate dehydrogenase in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Koszelewski, Dominik; Lavandera, Ivan; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2761 - 2766
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1 h; atmospheric pressure;
参考文献
Kim, Yongeun; Kang, Lae-Sung; Ha, Hyun-Joon; Ko, Seung Whan; Lee, Won Koo
Heterocycles, 2007 , vol. 71, # 10 p. 2243 - 2248
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; ω-transaminase ATA-117; pyridoxal 5'-phosphate; β-NADP+; lactate dehydrogenase in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 17 p. 2761 - 2766
反应条件
Candida antartica lipase B; triethylamine in n-heptane T=50°C; 25 h; Inert atmosphereEnzymatic reaction; optical yield given as percent ee;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 8171 - 8177
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; ω-transaminase ATA-117; pyridoxal 5'-phosphate; β-NADP+; lactate dehydrogenase in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 17 p. 2761 - 2766
反应条件
1: Candida antarctica lipase B 2: 3M aq. KOH / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 13 p. 2705 - 2717
反应条件
1: lithium aluminium tetrahydride / diethyl ether / 3 h / Inert atmosphere; Reflux 2: Candida antartica lipase B; triethylamine / 35 °C / Inert atmosphere; Enzymatic reaction 3: water; potassium hydroxide / Reflux View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 8171 - 8177
反应条件
1: ammonium acetate / Reflux 2: lithium aluminium tetrahydride / diethyl ether / 3 h / Inert atmosphere; Reflux 3: Candida antartica lipase B; triethylamine / 35 °C / Inert atmosphere; Enzymatic reaction 4: water; potassium hydroxide / Reflux View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 8171 - 8177
反应条件
1: With lithium aluminium tetrahydride in diethyl ether Reduction; 2 h; Heating; 2: With Candida antarctica lipase B; ethyl acetate; triethylamine T=30°C; racemate resolution; 4 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 13 p. 2705 - 2717
