3-甲基吡啶-2-甲酸乙酯合成路线 （共 6 条）
反应条件
hydrogenchloride in water 2 h; Heating / reflux;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: EP1180514 A1, 2002 ;
Location in patent: Example 103 ;
反应条件
1: 2-cyano-3-methyl-pyridine With hydrogenchloride; water Reflux; 2: ethanol With sulfuric acid Reflux;
参考文献
Lee, Ki Yong; Seob Lee, Kwang; Jin, Changbae; Lee, Yong Sup
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1331 - 1334
反应条件
1: 24 g / dimethyl sulphate / H2O / 5 h / 80 °C 2: sodium hydroxide, water / 4 h / Heating 3: 70 percent / hydrogen chloride (gas) / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1501 - 1505
反应条件
1: sodium hydroxide, water / 4 h / Heating 2: 70 percent / hydrogen chloride (gas) / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1501 - 1505
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice
View Scheme
参考文献
FIBROGEN, INC.; NG, Danny; AREND, Michael P.; FLIPPIN, Lee A.
Patent: WO2012/106472 A1, 2012 ;
WO 2012/106472 A1
反应条件
N-chloro-succinimide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane; acetic acid
T=60°C; Irradiationchlorinated reagent was added during 8 h;
参考文献
Clarke, Kenneth; Goulding, John; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1501 - 1505
