反应条件
1: 1percent aq. KOH / 6 h / Heating 2: (iPrO)3Al / propan-2-ol; acetone / 5.5 h / Heating 3: DMAP, pyridine / 3 h / Ambient temperature 4: 46 percent / aq. NaOH, monobasic potassium phosphate, Triton X-100 / lipase ex Pseudomonas fluorescens 5: 1.) n-BuLi / 1.) THF, hexane, 30 min, 2.) THF, hexane, RT, overnight 6: 96 percent / NaH, Pd(PPh3)4 / tetrahydrofuran / -78 - 20 °C 7: 99.9 percent / NaBH4 / methanol / 52 h 8: 100 percent / aq. NaOH / methanol; tetrahydrofuran / Heating 9: 45.9 percent / Me2NCH(OBu-t)2 / toluene / 60 °C 10: 1.) H2, 2.) H2 / 1.) 5percent Pt/C, 2.) 10percent Pd/C / 1.) EtOAc, 25 deg C, 500 psi, 4 h, 2.) EtOH, THF, 60 psi, 4 h View Scheme
参考文献
Coffen, David L.; Cohen, Noal; Pico, Anthony M.; Schmid, Rudolph; Sebastian, Mark J.; Wong, Frederick
Heterocycles, 1994 , vol. 39, # 2 p. 527 - 552
