2-氨基-4-氯苯甲酰胺合成路线 （共 22 条）
反应条件
hydrogenchloride in water; trimethyl orthoformate
参考文献
Japan Energy Corporation
Patent: EP1229025 A1, 2002 ;
反应条件
diethylene glycol T=120°C;
参考文献
McKee et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 184
反应条件
in 1-methyl-pyrrolidin-2-one
参考文献
Bartroli Orpi, Javier; Anguita Lopez, Manuel
Patent: US2003/64986 A1, 2003 ;
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
反应条件
1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: water; sodium hydroxide / 1 h / Reflux; Inert atmosphere 3: N,N-diethylaniline; trichlorophosphate / benzene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
参考文献
Hunn
Journal of the American Chemical Society, 1923 , vol. 45, p. 1028
反应条件
potassium carbonate; triethylamine; trifluoroacetic anhydride 1.) THF, 0 deg C, 30 min, 2.) CH3OH, H2O, 70 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 5 p. 754 - 765
参考文献
Hunn
Journal of the American Chemical Society, 1923 , vol. 45, p. 1028
反应条件
1: sulfuric acid 2: hydrogen chloride View Scheme
参考文献
Hunn
Journal of the American Chemical Society, 1923 , vol. 45, p. 1028
反应条件
1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: water; sodium hydroxide / 1 h / Reflux; Inert atmosphere View Scheme
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
