4-(羟基甲基)苯基特戊酸酯合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 2.5 h;
参考文献
Andrus, Merritt B.; Hicken, Erik J.; Stephens, Jeffrey C.; Bedke, D. Karl
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8651 - 8654
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=0°C; 1.5 h;
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
1: Et3N / tetrahydrofuran / 20 °C
2: NaBH4 / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
1: Et3N / tetrahydrofuran / 20 °C
2: NaBH4 / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
参考文献
Merck and Co., Inc.; Merck Frosst Canada, Inc.
Patent: US5182367 A1, 1993 ;
反应条件
pyridine; thionyl chloride in toluene
1 h; Heating;
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
methanesulfonyl chloride; triethylamine; lithium bromide in tetrahydrofuran
T=0°C; 2 h;
参考文献
Andrus, Merritt B.; Hicken, Erik J.; Stephens, Jeffrey C.; Bedke, D. Karl
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8651 - 8654
