3-碘-2,5-二甲基吡嗪合成路线 (共 2 条)
反应条件
1: 2,5-dimethyl-3-iodo-pyrazine With n-butyllithium in diethyl ether; hexane T=-35°C; 0.166667 h; 2: carbon dioxide With sodium hydroxide in water 3: With hydrogenchloride in water
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; KAWANISHI, Eiji; HONGU, Mitsuya; TANAKA, Yoshihito
Patent: WO2011/105628 A1, 2011 ;
Location in patent: Page/Page column 82 ;
WO 2011/105628 A1
参考文献
Merck Sharp and Dohme Limited
Patent: US5260293 A1, 1993 ;
US 5260293 A