1'-乙基螺[吲哚啉-3,4'-哌啶]-2-酮合成路线 (共 1 条)
反应条件
1: 1,3-dihydro-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 1,5-Dichloro-3-ethyl-3-azapentane, Hydrochloride in tetrahydrofuran
T=-78 - 20°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 47-48 ;
WO 2004/069256 A1