2,2,6,6-tetramethyl-piperidine; n-butyllithium; iodine in tetrahydrofuran; hexane T=-75°C; 2 h;

n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h;

1: 61 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2: 83 percent / butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C View Scheme