2,3-二氢-1H-吲哚-2-羧酸甲酯合成路线 （共 19 条）
反应条件
ammonia in methanol 6 h; Ambient temperature;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5616586 A1, 1997 ;
反应条件
potassium carbonate in acetonitrile T=0 - 20°C; 0.5 h;
参考文献
Dolle, Roland E.; Chu, Guo-Hua
Patent: US2005/54630 A1, 2005 ;
Location in patent: Page/Page column 49 ;
US 20050054630 A1
反应条件
triethylamine T=20°C; 1 h;
参考文献
Lavrenov, Sergei N.; Lakatosh, Sergei A.; Lysenkova, Ludmila N.; Korolev, Alexander M.; Preobrazhenskaya, Maria N.
Synthesis, 2002 , # 3 p. 320 - 322
反应条件
1: 96 percent / LiAlH4 / tetrahydrofuran / 3.5 h / Heating 2: imidazole, triphenylphosphine, iodine / toluene; acetonitrile / 0.17 h View Scheme
参考文献
Nagata, Ryu; Tanno, Norihiko; Kodo, Toru; Ae, Nobuyuki; Yamaguchi, Hiroshi; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3956 - 3968
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; diethyl ether; water
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5616586 A1, 1997 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3.5 h; Heating;
参考文献
Nagata, Ryu; Tanno, Norihiko; Kodo, Toru; Ae, Nobuyuki; Yamaguchi, Hiroshi; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3956 - 3968
参考文献
Kurokawa, Masayuki; Sugai, Takeshi
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 5 p. 1021 - 1025
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C 2: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; methanol / 2 h / 20 °C View Scheme
参考文献
Laborda, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Parella, Teodor; Joglar, Jesus; Clapes, Pere
Organic Letters, 2014 , vol. 16, # 5 p. 1422 - 1425
反应条件
1: Et3N / 1 h / 20 °C 2: 750 mg / Ac2O; HNO3 / 1.5 h / 0 °C 3: aq. HCl / Heating 4: 350 mg / SOCl2 / 20 °C 5: 78 percent / γ-MnO2 / toluene / 1 h / Heating View Scheme
参考文献
Lavrenov, Sergei N.; Lakatosh, Sergei A.; Lysenkova, Ludmila N.; Korolev, Alexander M.; Preobrazhenskaya, Maria N.
Synthesis, 2002 , # 3 p. 320 - 322
反应条件
1: 69 percent / 40 h / 20 °C 2: 49 percent / Chirazyme L-2 / aq. phosphate buffer / 30 h / 60 °C / pH 7.0 View Scheme
参考文献
Kurokawa, Masayuki; Sugai, Takeshi
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 5 p. 1021 - 1025
