N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺合成路线 （共 5 条）
反应条件
1: 87 percent / H2SO4 / methanol 2: acetonitrile / 0.67 h 3: KOH / acetonitrile View Scheme
参考文献
Manley, Jerad M.; Kalman, Monica J.; Conway, Brian G.; Ball, Cynthia C.; Havens, Jeffrey L.; Vaidyanathan, Rajappa
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6447 - 6450
反应条件
hydrogen; palladium on activated charcoal in acetic acid
T=65°C; Knorr pyrrole reaction; P=2327.17 Torr; 7 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 100 percent / aq. NaNO2; AcOH
2: 58 percent / Zn; AcOH
View Scheme
参考文献
Wang, Ji-Quan; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4380 - 4384
反应条件
1: various solvent(s) / 0 - 20 °C
2: 77 percent / H2 / Pd/C / acetic acid / 7 h / 65 °C / 2327.17 Torr
View Scheme
参考文献
Manley, Jerad M.; Kalman, Monica J.; Conway, Brian G.; Ball, Cynthia C.; Havens, Jeffrey L.; Vaidyanathan, Rajappa
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6447 - 6450
反应条件
sulfuric acid in methanol; water
T=65°C; 3.5 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
