N-(2-(二乙基氨基)乙基)-2,4-二甲基-1H-吡咯-3-甲酰胺合成路线 （共 8 条）
反应条件
1: N,N-dimethyl-formamide; N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide With phosgene in acetonitrile T=20°C; 2: 5-Fluoro-1,3-dihydro-2H-indol-2-one With potassium hydroxide in acetonitrile T=20°C; Product distribution / selectivity;
参考文献
RATIOPHARM GMBH; CHRIST, Jochen; STRIEGEL, Hans-Guenter
Patent: WO2010/136458 A1, 2010 ;
Location in patent: Page/Page column 27; 28 ;
反应条件
1: N-(chloromethylene)-N-methylmethanaminium chloride; N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide in acetonitrile 0.916667 h; 2: 5-Fluoro-1,3-dihydro-2H-indol-2-one With potassium hydroxide in acetonitrile T=20°C; 3.5 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
1: acetonitrile / 0.67 h 2: KOH / acetonitrile View Scheme
参考文献
Manley, Jerad M.; Kalman, Monica J.; Conway, Brian G.; Ball, Cynthia C.; Havens, Jeffrey L.; Vaidyanathan, Rajappa
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6447 - 6450
反应条件
sulfuric acid in methanol; water
T=65°C; 3.5 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
1H-imidazole; carbon dioxide in tetrahydrofuran
T=45°C;
参考文献
Vaidyanathan, Rajappa; Kalthod, Vikram G.; Ngo, Duc P.; Manley, Jerad M.; Lapekas, Sean P.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2565 - 2568
反应条件
1: 58 percent / Zn; AcOH
2: 87 percent / H2SO4 / methanol
View Scheme
参考文献
Wang, Ji-Quan; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4380 - 4384
反应条件
1: tetrahydrofuran / 45 °C
2: imidazole / carbon dioxide / tetrahydrofuran / 45 °C
View Scheme
参考文献
Vaidyanathan, Rajappa; Kalthod, Vikram G.; Ngo, Duc P.; Manley, Jerad M.; Lapekas, Sean P.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2565 - 2568
反应条件
1: various solvent(s) / 0 - 20 °C
2: 77 percent / H2 / Pd/C / acetic acid / 7 h / 65 °C / 2327.17 Torr
3: 100 percent / H2SO4 / methanol; H2O / 3.5 h / 65 °C
View Scheme
参考文献
Manley, Jerad M.; Kalman, Monica J.; Conway, Brian G.; Ball, Cynthia C.; Havens, Jeffrey L.; Vaidyanathan, Rajappa
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6447 - 6450
