1: With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=0°C; 1 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in hexane T=-78 - 0°C; 1.5 h; Further stages.;

in water T=50°C; 20 h;

in water T=50°C; 18 h;

1: H2NNH2*H2O / tetrahydrofuran / 20 h / 50 °C 2: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C 3: 67 percent / CuSO4*5H2O / H2O / 0.75 h / Heating 4: 88 percent / H2O / 20 h / 50 °C View Scheme

1.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C 1.2: 64 percent / I2 / tetrahydrofuran; hexane / 0.25 h / -75 °C 2.1: isobutylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 2.2: 94 percent / N-chlorosuccinimide / tetrahydrofuran / 0.75 h 3.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C 3.2: 92 percent / tetrahydrofuran; hexane 4.1: H2NNH2*H2O / tetrahydrofuran / 20 h / 50 °C 5.1: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C 6.1: 67 percent / CuSO4*5H2O / H2O / 0.75 h / Heating 7.1: 88 percent / H2O / 20 h / 50 °C View Scheme

1.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C 1.2: 92 percent / tetrahydrofuran; hexane 2.1: H2NNH2*H2O / tetrahydrofuran / 20 h / 50 °C 3.1: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C 4.1: 67 percent / CuSO4*5H2O / H2O / 0.75 h / Heating 5.1: 88 percent / H2O / 20 h / 50 °C View Scheme

1.1: isobutylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 1.2: 94 percent / N-chlorosuccinimide / tetrahydrofuran / 0.75 h 2.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.2: 92 percent / tetrahydrofuran; hexane 3.1: H2NNH2*H2O / tetrahydrofuran / 20 h / 50 °C 4.1: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C 5.1: 67 percent / CuSO4*5H2O / H2O / 0.75 h / Heating 6.1: 88 percent / H2O / 20 h / 50 °C View Scheme

1: 67 percent / CuSO4*5H2O / H2O / 0.75 h / Heating 2: 88 percent / H2O / 20 h / 50 °C View Scheme

tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis-(diphenylphosphino)propane; sodium t-butanolate in deuterated toluene T=80°C; Buchwald-Hartwig Coupling; 36 h; Schlenk techniqueInert atmosphere;