2-苯基-1H-吲哚-3-羧酸合成路线 （共 10 条）
反应条件
1: toluene / 12 h 2: water; acetonitrile / 5 h / |Reflux View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
1: With lithium tert-butylate in N,N-dimethyl-formamide
T=100°C; P=760.051 Torr; 24 h;
2: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
Yoo, Woo-Jin; Capdevila, Montse Guiteras; Du, Xiangwei; Kobayashi, Shu
Organic Letters, 2012 , vol. 14, # 20 p. 5326 - 5329,4
反应条件
1: H2 / 10percent Pd-C / methanol
2: methanol / 25 °C
3: acetonitrile / 4 h / 80 °C
View Scheme
参考文献
Grigg, Ronald; Gunaratne, H. Q. Nimal
Journal of the Chemical Society, Chemical Communications, 1984 , # 10 p. 661 - 662
反应条件
dimethyl amine in acetic acid
T=0°C; pH=12; 3 h;
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
ethanol; dihydrogen peroxide
参考文献
Sprio; Madonia
Gazzetta Chimica Italiana, 1957 , vol. 87, p. 454,465
反应条件
1: methanol / 25 °C
2: acetonitrile / 4 h / 80 °C
View Scheme
参考文献
Grigg, Ronald; Gunaratne, H. Q. Nimal
Journal of the Chemical Society, Chemical Communications, 1984 , # 10 p. 661 - 662
反应条件
1: dioxane; selenium dioxide
2: ethanol; aqueous H2O2
View Scheme
参考文献
Sprio; Madonia
Gazzetta Chimica Italiana, 1957 , vol. 87, p. 454,465
参考文献
Wacker, Dean A; Kasireddy, Padmaja
Tetrahedron Letters, 2002 , vol. 43, # 29 p. 5189 - 5191
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
1: toluene / 12 h
2: water; acetonitrile / 5 h / |Reflux
3: hydrogenchloride; water / 1,4-dioxane / 2 h / |Reflux
View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
