1-甲基-2-苯基-1H-吲哚-3-羧酸合成路线 （共 10 条）
反应条件
dimethylaluminum chloride in hexane; toluene
T=20°C; Friedel-Crafts reaction; P=22502.3 Torr; 3 h; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4512 - 4514
反应条件
N-methyl-2,3-diphenyl-1H-indole; water in ethanol
8 h; HeatingInert atmosphere;
参考文献
Miyasaka, Mitsuru; Fukushima, Azusa; Satoh, Tetsuya; Hirano, Koji; Miura, Masahiro
Chemistry - A European Journal, 2009 , vol. 15, # 15 p. 3674 - 3677
反应条件
palladium diacetate; caesium carbonate; tri-cyclo-hexyl-phosphine in o-xylene
4 h; Inert atmosphereReflux;
参考文献
Miyasaka, Mitsuru; Fukushima, Azusa; Satoh, Tetsuya; Hirano, Koji; Miura, Masahiro
Chemistry - A European Journal, 2009 , vol. 15, # 15 p. 3674 - 3677
反应条件
1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
2: sodium hydroxide / water; ethanol / 15 h / 80 °C
View Scheme
参考文献
Zhang, Xiang; Zhang-Negrerie, Daisy; Deng, Jun; Du, Yunfei; Zhao, Kang
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12750 - 12759
反应条件
1: acetic acid / 20 h / 80 °C / |Inert atmosphere
2: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere
3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
4: sodium hydroxide / water; ethanol / 15 h / 80 °C
View Scheme
参考文献
Zhang, Xiang; Zhang-Negrerie, Daisy; Deng, Jun; Du, Yunfei; Zhao, Kang
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12750 - 12759
反应条件
1: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere
2: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
3: sodium hydroxide / water; ethanol / 15 h / 80 °C
View Scheme
参考文献
Zhang, Xiang; Zhang-Negrerie, Daisy; Deng, Jun; Du, Yunfei; Zhao, Kang
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12750 - 12759
反应条件
1: acetic acid / 20 h / 80 °C / |Inert atmosphere
2: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere
3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
4: sodium hydroxide / water; ethanol / 15 h / 80 °C
View Scheme
参考文献
Zhang, Xiang; Zhang-Negrerie, Daisy; Deng, Jun; Du, Yunfei; Zhao, Kang
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12750 - 12759
反应条件
potassium hydroxide; ethylene glycol
参考文献
Ames et al.
Journal of the Chemical Society, 1959 , p. 3388,3396
参考文献
Borsche; Klein
Justus Liebigs Annalen der Chemie, 1941 , vol. 548, p. 74,80
反应条件
thionyl chloride
Behandeln des erhaltenen Saeurechlorids mit Benzol und Aluminiumchlorid;
参考文献
Borsche; Klein
Justus Liebigs Annalen der Chemie, 1941 , vol. 548, p. 74,80
