1-甲基-2-[(E)-2-苯基乙烯基]-1H-苯并咪唑合成路线 （共 17 条）
反应条件
1: hydrochloric acid / ethanol / Heating
2: potassium carbonate / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
van den Berg, Deidre; Zoellner, Kevin R.; Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3692 - 3702
反应条件
1: N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine; imidazole / dimethylformamide / 4 h / 20 °C
2: hydrochloric acid / ethanol / Heating
3: potassium carbonate / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
van den Berg, Deidre; Zoellner, Kevin R.; Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3692 - 3702
反应条件
1: N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine; imidazole / dimethylformamide / 4 h / 20 °C
2: hydrochloric acid / ethanol / Heating
3: potassium carbonate / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
van den Berg, Deidre; Zoellner, Kevin R.; Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3692 - 3702
反应条件
1: 1) boric acid, 2) DMF / 1) 180-190 h, 2-3 h, 2) 150 deg C, 0.5 h
2: 43 percent / 40percent NaOH / ethanol
View Scheme
参考文献
Popov
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 8 p. 949 - 953
参考文献
Ramaiah; Dubey; Eswara Rao; Ramanatham; Kumar; Grossert; Hooper
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 12 p. 904 - 914
反应条件
1: 1), 2) DMF / 1) fusing, 3 h, 2) reflux, 2 h
2: 90 percent / sodium bicarbonate, sodium sulfate / H2O; acetone / Heating
View Scheme
参考文献
Popov
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 8 p. 949 - 953
反应条件
1: triethylamine; phosphonic acid diethyl ester / 1.5 h / 20 °C
2: copper(l) iodide; palladium diacetate; lithium tert-butylate / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere
View Scheme
参考文献
Vabre, Roxane; Chevot, Franciane; Legraverend, Michel; Piguel, Sandrine
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9542 - 9547
