1-乙酰基哌啶-4-酰基氯合成路线 （共 28 条）
反应条件
thionyl chloride T=20°C; 2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1359145 A1, 2003 ;
Location in patent: Page/Page column 34-35 ;
参考文献
Warner-Lambert Co.; Cocensys, Inc.
Patent: US6218404 B1, 2001 ;
US 6218404 B1
参考文献
Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus
Patent: US2002/45615 A1, 2002 ;
反应条件
1: dichloromethane / 12 h / 20 °C 2: thionyl chloride / 0.5 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 71, p. 259 - 266
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 2: aq. HCl / Heating View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
1: AlCl3 / 1,2-dichloro-ethane / Heating 2: aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane Friedel Crafts acylation; Cooling with iceReflux;
参考文献
Liu, Zong-Ying; Li, Zhuo-Rong; Jiang, Jian-Dong; Boykin, David W.
Heterocyclic Communications, 2009 , vol. 15, # 6 p. 401 - 405
反应条件
aluminium trichloride in o-di-fluorobenzene
参考文献
Warner-Lambert Co.; Cocensys, Inc.
Patent: US6218404 B1, 2001 ;
US 6218404 B1
反应条件
aluminium trichloride in o-di-fluorobenzene
参考文献
A. H. Robins Company, Incorporated
Patent: US4950674 A1, 1990 ;
反应条件
aluminium trichloride in 1,2-dichloro-ethane Friedel-Crafts reaction; 2 h; Heating;
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
