1-乙酰基哌啶-4-酰基氯合成路线 （共 28 条）
反应条件
aluminium trichloride in dichloromethane
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 3 p. 903 - 905
反应条件
aluminium trichloride in 1,2-dichloro-ethane
4 h; Heating; Yield given;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3 / 2 h / Heating
2: 68 percent / 6 N aq. HCl / 6 h / Heating
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3 / 2 h / Heating
2: 68 percent / 6 N aq. HCl / 6 h / Heating
3: 76 percent / NaHCO3 / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
2: aq. HCl / Heating
3: 89 percent / HCOOH / 3 h / 55 - 60 °C
4: 90 percent / NaBH4 / methanol; H2O / Heating
View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
ammonia in 1,4-dioxane
18.1667 h;
参考文献
Wendt, Michael D.; Sun, Chaohong; Sauer, Daryl R.; Elmore, Steven W.; Kunzer, Aaron R.
Patent: US2007/72833 A1, 2007 ;
Location in patent: Page/Page column 30 ;
反应条件
aluminium trichloride in 1,2-dichloro-ethane
Friedel-Crafts reaction; Heating;
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
aluminium trichloride
2 h; Heating;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
