4-氧代-4-噻吩-2-基-丁酸乙酯合成路线 （共 8 条）
反应条件
1.1: 78 percent / NaOH / aq. ethanol / 1 h / Heating 2.1: DCC; BtOH / CH2Cl2 / 0.5 h / 0 - 20 °C 2.2: 67 percent / CH2Cl2 / 20 °C 3.1: 64 percent / Lawesson's reagent / toluene / 0.42 h / Heating View Scheme
参考文献
Heterocycles, , vol. 55, # 8 p. 1487 - 1498
反应条件
sodium hydroxide in ethanol 1 h; Heating;
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
反应条件
allyl bromide; 1,1'-carbonyldiimidazole
1.) CHCl3, 0.5 h, r.t.; 2.) CHCl3, r.t., 1 h; Yield given. Multistep reaction;
参考文献
Kamijo, Tetsuhide; Harada, Hiromu; Iizuka, Kinji
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 5044 - 5047
反应条件
tin(IV) chloride in dichloromethane
T=20°C; Friedel-Crafts;
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
反应条件
1: 4-(2'-thienyl)-4-oxobutanoic acid; chloroformic acid ethyl ester With triethylamine in N,N-dimethyl-formamide
T=-5°C; 0.25 h;
2: diisopropylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
反应条件
toluene-4-sulfonic acid in benzene
16 h; Heating;
参考文献
Hoffman, Robert V.; Kim, Hwa-Ok
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5107 - 5113
反应条件
1: 100 percent / SOCl2 / CH2Cl2 / Heating
2: 83 percent / SnCl4 / CH2Cl2 / 20 °C
View Scheme
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
反应条件
in tetrahydrofuran
1.5 h;
参考文献
Perner, Richard J.; Gu, Yu-Gui; Lee, Chih-Hung; Bayburt, Erol K.; McKie, Jeffery; Alexander, Karen M.; Kohlhaas, Kathy L.; Wismer, Carol T.; Mikusa, Joe; Jarvis, Michael F.; Kowaluk, Elizabeth A.; Bhagwat, Shripad S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 24 p. 5249 - 5257
