2',4'-二氟[1,1'-联苯]-4-基乙酸酯合成路线 (共 5 条)
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
hydrogenchloride; potassium carbonate
参考文献
Merck and Co., Inc.
Patent: US4131618 A1, 1978 ;
反应条件
1: 95 percent / pyridine / 14 h / 20 °C
2: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 20 h / Heating
View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; toluene
Suzuki coupling; 20 h; Heating;
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
(i) AlCl3, CS2, (ii) aq. H2O2, (CF3CO)2O, CH2Cl2; Multistep reaction;
参考文献
Hannah,J. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 1093 - 1100