4-(2,4-二氟苯基)苯酚合成路线 （共 8 条）
反应条件
hydrogenchloride; triphenylphosphine; palladium on charcoal in toluene
参考文献
ZAMBON GROUP S.p.A.
Patent: EP494419 A2, 1992 ;
反应条件
potassium carbonate; [Pd(P{(C6H11)3})2] in water; N,N-dimethyl-formamide Inert atmosphereReflux;
参考文献
Hoffmann-La Roche Inc.
Patent: US7939569 B1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogen bromide in acetic acid
参考文献
Journal of Medicinal Chemistry, , vol. 21, p. 1093 - 1100
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 20 h / Heating 2: Na / methanol / 12 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 2 p. 355 - 374
反应条件
1: 95 percent / pyridine / 14 h / 20 °C 2: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 20 h / Heating 3: Na / methanol / 12 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 2 p. 355 - 374
反应条件
1: (i) AlCl3, CS2, (ii) aq. H2O2, (CF3CO)2O, CH2Cl2 2: aq. NaOH View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 21, p. 1093 - 1100
反应条件
1: 74 percent / aq. NaOH / 5 h / 100 °C 2: 1.) NaH / 1.) DMF, 100 deg C, 15 min, 2.) DMF, 100 deg C, 3 h View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 56, # 11.1 p. 2373 - 2381
