4-氯-2-甲硫基嘧啶-5-羧酸乙酯合成路线

参考文献

ELI LILLY AND COMPANY; DECIPHERA PHARMACEUTICALS, LLC; ALLGEIER, Matthew Carl; FLYNN, Daniel L.; KAUFMAN, Michael D.; PATEL, Phenil J.; WOLFANGEL, Craig D.
Patent: WO2013/134243 A1, 2013 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯+

144-55-8碳酸氢钠

51940-64-82,4-二氯-5-嘧啶甲酸乙酯

参考文献

Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei
Patent: US2003/32647 A1, 2003 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

57401-76-02-氨基嘧啶-5-甲酸乙脂

参考文献

CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria
Patent: WO2013/45280 A1, 2013 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

770-31-04-氨基-2-甲巯基嘧啶-5-甲醛

参考文献

ELI LILLY AND COMPANY; DECIPHERA PHARMACEUTICALS, LLC; ALLGEIER, Matthew Carl; FLYNN, Daniel L.; KAUFMAN, Michael D.; PATEL, Phenil J.; WOLFANGEL, Craig D.
Patent: WO2013/134243 A1, 2013 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

74840-34-94-氯-2-(甲基硫代)嘧啶-5-羧酸

参考文献

Player, Mark R.; Parsons, William H.; Huang, Hui; Hutta, Daniel A.; Hu, Huaping; Rinker, James
Patent: US2008/114007 A1, 2008 ;
Location in patent: Page/Page column 82 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯+

74-89-5甲胺

76360-82-24-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯

参考文献

Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

76360-82-24-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯

参考文献

Chen, Jian Jeffrey; Dunn, James Patrick; Goldstein, David Michael; Stahl, Christoph Martin
Patent: US2003/171584 A1, 2003 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯+

593-51-1盐酸甲胺

76360-82-24-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯

参考文献

TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; REDDY, E., Premkumar; REDDY, M.V., Ramana
Patent: WO2011/75616 A1, 2011 ;
Location in patent: Page/Page column 62 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

76360-82-24-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯+

185040-32-84-甲胺基-2-甲硫基-5-醛基嘧啶

参考文献

Warner-Lambert Company
Patent: US5733914 A1, 1998 ;

5909-24-04-氯-2-甲硫基嘧啶-5-羧酸乙酯

73781-88-12-甲硫基-5-嘧啶羧酸乙酯

参考文献

METHYLGENE INC.
Patent: US2008/227826 A1, 2008 ;
Location in patent: Page/Page column 27-28 ;
US 20080227826 A1