5-叠氮基甲基-2'-脱氧尿苷合成路线 （共 6 条）
反应条件
sodium azide in trifluoroacetic acid
T=20°C;
参考文献
Xu, Xiaowei; Yan, Shengyong; Hu, Jianlin; Guo, Pu; Wei, Lai; Weng, Xiaocheng; Zhou, Xiang
Tetrahedron, 2013 , vol. 69, # 46 p. 9870 - 9874
反应条件
ammonium hydroxide in 1,4-dioxane
参考文献
Hong, In Seok; Ding, Hui; Greenberg, Marc M.
Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491
反应条件
sodium periodate; sodium azide in phosphate buffer
T=37°C; pH=7.2; 0.5 h;
参考文献
Hong, In Seok; Ding, Hui; Greenberg, Marc M.
Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491
反应条件
1: 250 mg / NaN3 / dimethylformamide
2: 90 percent / aq. NH3 / dioxane
View Scheme
参考文献
Hong, In Seok; Ding, Hui; Greenberg, Marc M.
Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491
反应条件
1: N-bromosuccinimide; AIBN / benzene / 3 h / Heating
2: 250 mg / NaN3 / dimethylformamide
3: 90 percent / aq. NH3 / dioxane
View Scheme
参考文献
Hong, In Seok; Ding, Hui; Greenberg, Marc M.
Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491
反应条件
pyridine; lithium azide; p-toluenesulfonyl chloride
1.) 3 deg C, 1 d, 2.) DMF, 85 deg C, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Shiau, George T.; Schinazi, Raymond F.; Chen, Ming S.; Prusoff, William H.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 127 - 133
