1: acetic acid 2: alkali 3: diluted hydrochloric acid View Scheme

1: ethyl acetate / Reflux 2: sulfuric acid / 0 °C 3: sulfuric acid; acetic acid / Reflux 4: pyridine / dichloromethane / 20 °C 5: caesium carbonate / acetonitrile / 80 °C 6: sulfuric acid / 12 h / 90 °C View Scheme

1: sodium hydroxide / ethyl acetate / 5 h / 80 °C 2: AlCl3, aluminium chloride / 5 h / 135 °C 3: hydrogenchloride / water / 3 h / 50 °C View Scheme

in tetrahydrofuran Reflux;

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / |Large scale 1.2: 1 h / 0 °C / |Large scale 1.3: 2.5 h / 0 - 20 °C / |Large scale 2.1: potassium carbonate / acetone / 55 °C 3.1: AlCl3, aluminium chloride / dichloromethane / 2.5 h / 0 - 20 °C / |Inert atmosphere 4.1: norborn-2-ene; palladium diacetate; triphenylphosphine; caesium carbonate / 12 h / 80 °C 5.1: titanium tetraethoxide / tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere 5.2: 24 h / 60 °C / |Inert atmosphere 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -78 °C / |Inert atmosphere; |Heating 7.1: hydrogenchloride; water / methanol / 4 h / 0 - 20 °C / |Inert atmosphere 8.1: palladium 10 on activated carbon; hydrogen / ethyl acetate; acetic acid / 24 h / 45 °C / 2068.65 Torr 9.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / |Inert atmosphere 10.1: triethylamine / dichloromethane / 1 h / 20 °C 11.1: potassium phtalimide / N,N-dimethyl-formamide / 1 h / 100 °C 11.2: 3 h / |Reflux 12.1: triethylamine / dichloromethane / 20 °C View Scheme

1: 62 percent / pyridine / tetrahydrofuran / 14 h / 20 °C 2: 67 percent / aq. sulfuric acid / 4 h / 20 °C 3: 63 percent / H2SO4; glacial acetic acid / 2 h / 125 °C View Scheme

暂无反应条件数据

1: 89 percent / ethyl acetate / Heating 2: 2.) 75percent aq. H2SO4 / 2.) 25 deg C View Scheme

1: 94 percent / KHCO3 / ethyl acetate; H2O / 4 h 2: 87.5 percent / conc. H2SO4 / 2 h View Scheme

1H-imidazole in tetrahydrofuran T=20°C; Inert atmosphere;