反应条件
1.1: ammonium acetate; acetic acid / 12 h / 100 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 3.1: hydrogenchloride / water / 1 h / 60 °C 4.1: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 5.1: hydrogen bromide; water / 5 h / |Reflux 6.1: triethylamine / tetrahydrofuran; water 7.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 7.2: 1 h 8.1: hydrogenchloride / water; ethanol / 6 h / 20 °C View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418