反应条件
1: SOCl2 / 1 h / Ambient temperature 2: 32 percent / pyridine / CH2Cl2 / Ambient temperature 3: 1.) 9-BBN, 2.) 1M aq. NaOH, 27percent aq. H2O2 / 1.) THF, RT, 3 h, 2.) THF, 40 deg C, 1 h 4: CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature 5: 1.) NaH, 2.) KI / 1.) DMF, RT, 10 min, 2.) DMF, 70 deg C, 4 h 6: 90 percent / borane-THF complex / tetrahydrofuran / 1 h / Heating 7: 90 percent / LiOH*H2O / dioxane; H2O / 1 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
