3-溴吡唑并[1,5-a]吡啶合成路线 （共 4 条）
反应条件
N-bromosuccinmide; sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
ALMIRALL, S.A.; BACH TANA, Jordi; PAGES SANTACANA, Lluis, Miquel; TALTAVULL MOLL, Joan; EASTWOOD, Paul, Robert; GONZALEZ RODRIGUES, Jacob; GIULIO MATASSA, Victor
Patent: WO2011/101161 A1, 2011 ;
Location in patent: Page/Page column 99 ;
WO 2011/101161 A1
反应条件
1: sodium hydroxide; water / ethanol / 1 h / Reflux 2: sodium hydrogencarbonate; N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C View Scheme
参考文献
WO2011/101161 A1, ;
WO 2011/101161 A1
反应条件
potassium carbonate; tri-cyclo-hexyl-phosphine; palladium diacetate in diethylene glycol dimethyl ether; water T=100°C; Suzuki-Miyaura reaction; 2 h;
参考文献
ALMIRALL, S.A.; BACH TANA, Jordi; PAGES SANTACANA, Lluis, Miquel; TALTAVULL MOLL, Joan; EASTWOOD, Paul, Robert; GONZALEZ RODRIGUES, Jacob; GIULIO MATASSA, Victor
Patent: WO2011/101161 A1, 2011 ;
Location in patent: Page/Page column 103 ;
WO 2011/101161 A1
反应条件
n-butyllithium in tetrahydrofuran T=-78 - 20°C;
参考文献
MERCK and CO., INC.; KATZ, Jason; KNOWLES, Sandra, L.; JEWELL, James, P.; SLOMAN, David, L.; STANTON, Matthew, G.; NOUCTI, Njamkou
Patent: WO2010/17046 A1, 2010 ;
Location in patent: Page/Page column 47; 126-127 ;
WO 2010/017046 A1
