(6CI,7CI)-2-对甲苯萘合成路线 （共 62 条）
反应条件
potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl in water
T=50°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Uozumi, Yasuhiro; Nakai, Yasushi
Organic Letters, 2002 , vol. 4, # 17 p. 2997 - 3000
反应条件
lithium chloride in tetrahydrofuran; toluene
T=110°C; 48 h; Inert atmosphere;
参考文献
Shirakawa, Eiji; Okura, Keisho; Uchiyama, Nanase; Murakami, Takuya; Hayashi, Tamio
Chemistry Letters, 2014 , vol. 43, # 6 p. 922 - 924
反应条件
caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)) in 1,4-dioxane
T=90°C; Suzuki-Miyaura cross-coupling reaction; 20 h;
参考文献
Kuriyama, Masami; Shimazawa, Rumiko; Shirai, Ryuichi
Tetrahedron, 2007 , vol. 63, # 38 p. 9393 - 9400
反应条件
X-Phos; tetrabutyl ammonium fluoride; palladium diacetate in tetrahydrofuran
T=80°C; Hiyama coupling; Inert atmosphere;
参考文献
Zhang, Liang; Wu, Jie
Journal of the American Chemical Society, 2008 , vol. 130, # 37 p. 12250 - 12251
反应条件
1: para-bromotoluene With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - 20°C; Inert atmosphere;
2: With zinc(II) chloride in tetrahydrofuran; pentane
T=0 - 20°C; Inert atmosphere;
3: 2-naphthyl 2,2,2-trimethylacetate With Ni(PCy3)2Cl2 in tetrahydrofuran; N,N-dimethyl acetamide; pentane
T=70°C; 2 h; Inert atmosphere;
参考文献
Li, Bi-Jie; Li, Yi-Zhou; Lu, Xing-Yu; Liu, Jia; Guan, Bing-Tao; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2008 , vol. 47, # 52 p. 10124 - 10127
反应条件
1: p-methylphenylboronic acid T=75°C; 1 h; dehydrationvacuum;
2: 2-naphthyl diethylcarbamate With potassium phosphate; NiCl2(PCy3)2; PCy3∙HBF4 in o-xylene
T=150°C; Suzuki-Miyaura coupling; 5 h; Inert atmosphere;
参考文献
Antoft-Finch, Aurora; Blackburn, Tom; Snieckus, Victor
Journal of the American Chemical Society, 2009 , vol. 131, # 49 p. 17750 - 17752
反应条件
C68H72Cl2N6NiP2 in tetrahydrofuran
T=25°C; 24 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Chemistry - A European Journal, 2011 , vol. 17, # 18 p. 4972 - 4975
反应条件
1: (4-Methylphenyl)-magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane
T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere;
2: C10H7-2-OTs in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
反应条件
1: C30H21Al*C4H8O With palladium diacetate; tri-cyclo-hexyl-phosphine in toluene
T=100°C; 1 h;
2: para-bromotoluene in toluene
T=60°C; 5 h; Further stages.;
参考文献
Ku, Shih-Lun; Hui, Xin-Ping; Chen, Chien-An; Kuo, Yi-Ying; Gau, Han-Mou
Chemical Communications, 2007 , # 37 p. 3847 - 3849
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate in N,N-dimethyl acetamide; water
T=60°C; Suzuki-Miyaura cross-coupling;
参考文献
Albaneze-Walker, Jennifer; Raju, Ravinder; Vance, Jennifer A.; Goodman, Andrew J.; Reeder, Michael R.; Liao, Jing; Maust, Mathew T.; Irish, Patrick A.; Espino, Peter; Andrews, David R.
Organic Letters, 2009 , vol. 11, # 7 p. 1463 - 1466
