(R)-(-)-1-环己基乙胺合成路线 （共 19 条）
反应条件
hydrogen; acetic acid; platinum(IV) oxide in methanol P=3102.97 Torr; 18 h; Product distribution / selectivity;
参考文献
WO2008/79346 A1, ;
Page/Page column 66; 67 ;
WO 2008/079346 A1
反应条件
Alkaline protease in 3-methyl pentan-3-ol T=20°C; 3 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Nechab, Malek; El Blidi, Lahssen; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 21 p. 3917 - 3920
反应条件
Ni T=110°C; 2 h; Inert atmosphere; Reagent/catalystTime;
参考文献
Geukens, Inge; Plessers, Eva; Seo, Jin Won; De Vos, Dirk E.
European Journal of Inorganic Chemistry, 2013 , # 14 p. 2623 - 2628
反应条件
hydrogen; aluminum oxide; ruthenium
参考文献
Justus Liebigs Annalen der Chemie, , vol. 706, p. 37 - 46
反应条件
1: With (S)-isopropylidene glycerol 3-carboxy-2-naphthoate in methanol T=20°C; 2: With hydrogenchloride in ethyl acetate Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 20 p. 2277 - 2282
反应条件
1: conc.HCl / tetrahydrofuran 2: 1.) H2, 2.) samarium(II) iodide / 1.) <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- / 1.) -15 deg C, 36 h, isopropanol, 60 psi; 2.) methanol, THF, 30 min View Scheme
参考文献
Tetrahedron, , vol. 50, # 15 p. 4399 - 4428
反应条件
hydrogen; palladium on activated charcoal 24 h;
参考文献
Chemical Communications, , # 15 p. 1530 - 1531
参考文献
Tetrahedron Asymmetry, , vol. 9, # 4 p. 681 - 689
反应条件
transaminase ATA-113; pyridoxal 5'-phosphate; sodium 2-oxopropanoate T=30°C; pH=7.0; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
反应条件
samarium diiodide; hydrogen; 1.) <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- 1.) -15 deg C, 36 h, isopropanol, 60 psi; 2.) methanol, THF, 30 min; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 50, # 15 p. 4399 - 4428
