4-氯-6,7-亚甲基二氧基喹啉合成路线 （共 9 条）
反应条件
trichlorophosphate
2 h; Heating;
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
trichlorophosphate
5 h; Heating;
参考文献
Gall-Istok, K.; Sterk, L.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 241 - 252
反应条件
1: 52 percent / various solvent(s) / 1.5 h / Heating
2: 63 percent / phosphoryl chloride / 5 h / Heating
View Scheme
参考文献
Gall-Istok, K.; Sterk, L.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 241 - 252
反应条件
1: NaOH / ethanol; H2O / 48 h / Ambient temperature
2: 52 percent / various solvent(s) / 1.5 h / Heating
3: 63 percent / phosphoryl chloride / 5 h / Heating
View Scheme
参考文献
Gall-Istok, K.; Sterk, L.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 241 - 252
反应条件
1: PPE / 2 h / 120 °C
2: NaOH / ethanol; H2O / 48 h / Ambient temperature
3: 52 percent / various solvent(s) / 1.5 h / Heating
4: 63 percent / phosphoryl chloride / 5 h / Heating
View Scheme
参考文献
Gall-Istok, K.; Sterk, L.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 241 - 252
反应条件
1: 71 percent / benzene / 3.5 h / Heating
2: PPE / 2 h / 120 °C
3: NaOH / ethanol; H2O / 48 h / Ambient temperature
4: 52 percent / various solvent(s) / 1.5 h / Heating
5: 63 percent / phosphoryl chloride / 5 h / Heating
View Scheme
参考文献
Gall-Istok, K.; Sterk, L.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 241 - 252
反应条件
1: 89 percent / NaH / Heating
2: 91 percent / POCl3 / 2 h / Heating
View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
1: 4-chloro-6,7-methylenedioxyquinoline With phenol
2.5 h; Heating;
2: (2RS)-tetrahydro-2-furanylmethylamine in phenol
T=100°C; 20 h;
参考文献
Ruchelman, Alexander L.; Singh, Sudhir K.; Ray, Abhijit; Wu, Xiao Hua; Yang, Jin-Ming; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 9 p. 2061 - 2073
反应条件
1.1: phenol / 2.5 h / Heating
1.2: 65 percent / phenol / 20 h / Heating
2.1: 1.44 g / Et3N / CH2Cl2 / 16 h / Heating
3.1: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag2CO3 / dimethylformamide / 0.5 h / Heating
4.1: 95 percent / formic acid; AcOH / Pd black / 1.5 h / 20 °C
View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
