3-苯基螺[异苯并呋喃-1(3H),4'-哌啶]合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in isopropyl alcohol; toluene
T=75°C; P=2482.3 Torr; 5 h;
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: NaBH4 / ethanol
2: HCl
3: (i) nBuLi, THF, hexane, (ii) /BRN= 106924/, (iii) aq. HCl, AcOH
4: benzene / 18 h / Heating
5: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: (i) nBuLi, THF, hexane, (ii) /BRN= 106924/, (iii) aq. HCl, AcOH
2: benzene / 18 h / Heating
3: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: HCl
2: (i) nBuLi, THF, hexane, (ii) /BRN= 106924/, (iii) aq. HCl, AcOH
3: benzene / 18 h / Heating
4: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: aq. HCl / acetic acid / 0.17 h / Heating
2: benzene / 18 h / Heating
3: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
sodium hydroxide in ethanol
18 h; Heating;
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: benzene / 18 h / Heating
2: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
1: aq. HCl / acetic acid / 0.17 h / Heating
2: benzene / 18 h / Heating
3: aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
反应条件
sodium hydroxide in ethanol
18 h; Heating;
参考文献
Bauer; Duffy; Hoffman; Klioze; Kosley Jr.; McFadden; Martin; Ong
Journal of Medicinal Chemistry, 1976 , vol. 19, # 11 p. 1315 - 1324
