2,3-二甲基-6-硝基苯胺合成路线 （共 17 条）
反应条件
1: 1.) concd. aq. HCl, sodium nitrite, 2.) copper(I) cyanide / 1.) 5 deg C, 2.) H2O, RT, overnight 2: 1.) BH3-THF, 2.) 10percent HCl / 1.) overnight, 2.) reflux, 30 min 3: 1.) sodium nitrite, acetic acid, 2.) 1 N aq. NaOH / 1.) water, RT, 10 min, 2.) methanol 4: 93 percent / pyridinium chlorochromate / CH2Cl2 / 4 h View Scheme
参考文献
Meanwell; Roth; Smith; Wedding; Wright; Fleming; Gillespie
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2906 - 2916
反应条件
sodium hydroxide; zinc in ethanol; water 18 h; Reflux;
参考文献
CHEVRON U.S.A. INC.; RUTGERS, THE STATE UNIVERSITY OF NJ; Goldman, Alan Stuart; Stibrany, Robert Timothy; Schinski, William L.
Patent: US2013/90503 A1, 2013 ;
Location in patent: Paragraph 0042 ;
反应条件
sulfuric acid; acetic acid; sodium nitrite anschliessend Behandeln mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure;
参考文献
van Berk et al.
Recueil des Travaux Chimiques des Pays-Bas, 1956 , vol. 75, p. 1137,1138, 1149
反应条件
pyridinium hydrobromide perbromide; acetic acid 0.5 h; Ambient temperature;
参考文献
Grivas, Spiros; Tian, Wei; Ronne, Erik; Lindstroem, Stefan; Olsson, Kjell
Acta Chemica Scandinavica, 1993 , vol. 47, # 5 p. 521 - 528
反应条件
1: 95 percent / pyridinium bromide perbromide, AcOH / 0.5 h / Ambient temperature 2: 87 percent / 25percent aq. NH3, sodium dithionite / methanol / 3 h / Heating View Scheme
参考文献
Grivas, Spiros; Tian, Wei; Ronne, Erik; Lindstroem, Stefan; Olsson, Kjell
Acta Chemica Scandinavica, 1993 , vol. 47, # 5 p. 521 - 528
反应条件
acetic anhydride in acetic acid
参考文献
Daiichi Pure Chemicals Co., Ltd.; Nagano, Tetsuo
Patent: US6441197 B1, 2002 ;
反应条件
in acetic acid
Substitution; 1 h; Heating;
参考文献
Kojima, Hirotatsu; Nakatsubo, Naoki; Kikuchi, Kazuya; Kawahara, Shigenori; Kirino, Yutaka; Nagoshi, Hiroshi; Hirata, Yasunobu; Nagano, Tetsuo
Analytical Chemistry, 1998 , vol. 70, # 13 p. 2446 - 2453
