2-(4-硝基苯基)噻吩合成路线 （共 26 条）
反应条件
hydrazine hydrate in ethanol; hexane; platinum
参考文献
The United States of America as represented by the Secretary of the Air Force
Patent: US6130339 A1, 2000 ;
反应条件
1,4-diaza-bicyclo[2.2.2]octane; tetrabutyl ammonium fluoride; palladium diacetate in 1,4-dioxane
T=100°C; Stille reaction; 16 h;
参考文献
Li, Jin-Heng; Liang, Yun; Wang, De-Ping; Liu, Wen-Jie; Xie, Ye-Xiang; Yin, Du-Lin
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2832 - 2834
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide
24 h; Inert atmosphere;
参考文献
Powell, Adam B.; Brown, Jaclyn R.; Vasudevan, Kalyan V.; Cowley, Alan H.
Dalton Transactions, 2009 , # 14 p. 2521 - 2527
反应条件
tetrabutyl ammonium fluoride; tri-cyclo-hexyl-phosphine; dichloro bis(acetonitrile) palladium(II)
T=85 - 90°C; Suzuki-Miyaura reaction; 5 h;
参考文献
Li, Jin-Heng; Deng, Chen-Liang; Xie, Ye-Xiang
Synthetic Communications, 2007 , vol. 37, # 14 p. 2433 - 2448
反应条件
tetrakis (triphenylphosphine) palladium (0) in toluene
参考文献
The United States of America as represented by the Secretary of the Air Force
Patent: US6130339 A1, 2000 ;
反应条件
1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate in N,N-dimethyl-formamide
T=110°C; Suzuki-Miyaura cross-coupling; 10 h;
参考文献
Li, Jin-Heng; Zhu, Qi-Ming; Xie, Ye-Xiang
Tetrahedron, 2006 , vol. 62, # 47 p. 10888 - 10895
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran
T=-75°C; 1 h; Inert atmosphere;
2: With zinc(II) chloride−TMEDA in tetrahydrofuran
T=-75 - 20°C;
3: 1-bromo-4-nitro-benzene Further stages;
参考文献
Seggio, Anne; Priem, Ghislaine; Chevallier, Floris; Mongin, Florence
Synthesis, 2009 , # 21 p. 3617 - 3632
反应条件
sodium iodide; (4-nitrophenyl)Pd(P(C6H5)3)2I in N,N-dimethyl-formamide
cross-coupling react. of the corresponding (A)2Hg with the corresponding ArI in DMF in the presence of NaI and the Pd catalyst, vigorous stirring under Ar (20°C, 10 min); diln. with water, extn. (ether, 3 times), washing of exts. (aq. NaI soln.), drying of ether layer (MgSO4), evapn. to dryness;
参考文献
Bumagin, N. A.; More, P. G.; Beletskaya, I. P.
Journal of Organometallic Chemistry, 1989 , vol. 364, p. 231 - 234
反应条件
(i-Pent2(C6H3))2(C3H2N2))PdCl2((C5H4N)Cl) in tetrahydrofuran
T=23°C; Negishi Coupling; 24 h;
参考文献
Xu, Shiqing; Truex, Nicholas L.; Mohan, Swathi; Negishi, Ei-Ichi
Arkivoc, 2012 , vol. 2012, # 7 p. 242 - 252
反应条件
copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide
T=120°C; Hiyama Coupling; 12 h; Inert atmosphere;
参考文献
Gurung, Santosh K.; Thapa, Surendra; Vangala, Adarsh S.; Giri, Ramesh
Organic Letters, 2013 , vol. 15, # 20 p. 5378 - 5381
