2-(4-硝基苯基)噻吩合成路线 （共 26 条）
反应条件
1: thiophen-2-yl-MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 1-bromo-4-nitro-benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
bis(η3-allyl-μ-chloropalladium(II)) in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C; 0.7 h;
参考文献
Bumagin, N. A.; Bumagina, I. G.; Kashin, A. N.; Beletskaya, I. P.
Doklady Chemistry, 1981 , vol. 261, p. 532 - 535
Dokl. Akad. Nauk SSSR Ser. Khim., 1981 , vol. 261, # 5 p. 1141 - 1144
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate in toluene
Suzuki coupling;
参考文献
O'Connell, Daniel P.; Leblanc, Daniel F.; Cromley, Debra; Billheimer, Jeffrey; Rader, Daniel J.; Bachovchin, William W.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1397 - 1401
参考文献
Hardie; Thomson
Journal of the Chemical Society, 1957 , p. 2512,2517
反应条件
1: AlCl3 / CHCl3 / 24 h / Ambient temperature
2: 1.) 5percent KOH, 2.) 33percent H2O2 / 1.) ethanol, reflux, 1 h, 2.) water, reflux, 1 h
View Scheme
参考文献
Fusco, Raffaello; Sannicolo, Franco
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1691 - 1696
反应条件
1: AlCl3 / CHCl3 / 24 h / Ambient temperature
2: 1.) 5percent KOH, 2.) 33percent H2O2 / 1.) ethanol, reflux, 1 h, 2.) water, reflux, 1 h
3: 0.51 g / diethyl ether
View Scheme
参考文献
Fusco, Raffaello; Sannicolo, Franco
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1691 - 1696
