2,3,4,9-四氢-2-甲基-1H-吡啶并[3,4-b]吲哚-1-酮合成路线 （共 12 条）
反应条件
in ethanol
T=200 - 210°C; P=30002.4 - 33752.7 Torr; 48 h;
参考文献
Lehmann, Jochen; Pohl, Ursula
Archiv der Pharmazie (Weinheim, Germany), 1988 , vol. 321, p. 411 - 414
反应条件
formic acid
T=80°C; 0.5 h;
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
hydrogenchloride in water; isopropyl alcohol
3 h; Heating;
参考文献
Tokmakov, G.P.; Grandberg, I.I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 3 p. 244 - 247
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 3 p. 331 - 334
反应条件
1: 53.4 percent / KOH / methanol / 2.5 h / 20 - 40 °C
2: 1.) KOH / 1.) DMSO, 10 min, 2.) DMSO, 2 h
3: 3.7 g / H2 / Pd/C / methanol / 1 h / Ambient temperature
4: 95.1 percent / H2 / Ru/C / methanol / 15 h / 50 °C / 2250.2 Torr
5: 49.8 percent / Jones reagent / acetone / 10 h
7: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
1: 95.1 percent / H2 / Ru/C / methanol / 15 h / 50 °C / 2250.2 Torr
2: 49.8 percent / Jones reagent / acetone / 10 h
4: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
1: 1.) KOH / 1.) DMSO, 10 min, 2.) DMSO, 2 h
2: 3.7 g / H2 / Pd/C / methanol / 1 h / Ambient temperature
3: 95.1 percent / H2 / Ru/C / methanol / 15 h / 50 °C / 2250.2 Torr
4: 49.8 percent / Jones reagent / acetone / 10 h
6: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
1: 3.7 g / H2 / Pd/C / methanol / 1 h / Ambient temperature
2: 95.1 percent / H2 / Ru/C / methanol / 15 h / 50 °C / 2250.2 Torr
3: 49.8 percent / Jones reagent / acetone / 10 h
5: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
1: 49.8 percent / Jones reagent / acetone / 10 h
3: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
反应条件
hydrogenchloride in water; isopropyl alcohol
3 h; Heating;
参考文献
Tokmakov, G.P.; Grandberg, I.I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 3 p. 244 - 247
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 3 p. 331 - 334
反应条件
2: 55.1 percent / formic acid / 0.5 h / 80 °C
View Scheme
参考文献
Herdeis, Claus; Dimmerling, Anna
Heterocycles, 1984 , vol. 22, # 10 p. 2277 - 2283
