2-甲氧基-4-氨基-5-硫氰基苯甲酸甲酯合成路线 （共 5 条）
反应条件
bromine in methanol T=5 - 15°C; Industry scale;
参考文献
WO2011/158084 A1, ;
Page/Page column 11 ;
反应条件
bromine; acetic acid T=20°C;
参考文献
US2009/130076 A1, ;
Page/Page column 26; 27 ;
US 20090130076 A1
反应条件
1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale 2: bromine / methanol / 5 - 15 °C / Industry scale View Scheme
反应条件
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 2.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 3.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C View Scheme
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
反应条件
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 2.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 3.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C 4.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C View Scheme
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
