反应条件
1.1: tBuOK / N,N-dimethyl-acetamide / 0.5 h / 0 °C
1.2: N,N-dimethyl-acetamide / 1 h / 20 °C
1.3: aq. H2O2 / N,N-dimethyl-acetamide / 1 h / 0 °C
2.1: 58 percent / NH3 / ethanol / 16 h / 145 °C
View Scheme
参考文献
Hamdouchi, Chafiq; Sanchez-Martinez, Concha; Gruber, Joseph; Del Prado, Miriam; Lopez, Javier; Rubio, Almudena; Heinz, Beverly A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4333 - 4341
