6-[(2-甲基 -1-氧代烯丙基)氨基]己酸合成路线 （共 5 条）
反应条件
1: in tetrahydrofuran T=-15 - 20°C; 2: With acetic acid in tetrahydrofuran 1 h;
参考文献
Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts
Patent: EP1647283 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in tetrahydrofuran T=-18 - 4°C; 18 h;
参考文献
ZENTIVA, A.S.
Patent: WO2007/110003 A2, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
1: N-methacryloyl-6-aminohexanoic acid; triethylamine With isobutyl chloroformate in tetrahydrofuran T=-10°C; 0.166667 h; 2: Asp-[Asp-(OMe)2]2 trifluoroacetic acid in tetrahydrofuran T=20°C; 4 h;
参考文献
Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts
Patent: EP1647283 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 6-amino-hexanoic acid With hydroquinone; sodium hydroxide in water
Cooling with ice;
2: 2-methyl-acryloyl chloride With sodium hydroxide in water
T=20°C; pH=9 - 10; 3 h;
参考文献
Grachev; Bakova; Makhonina; Yurieva; Aldoshin; Gorelik; Barachevskii
Russian Chemical Bulletin, 2011 , vol. 60, # 7 p. 1469 - 1475
反应条件
in methanol; glacial acetic acid methacrylic anhydride; chloroform
参考文献
Golova, Julia B.; Chernov, Boris K.
Patent: US2006/194213 A1, 2006 ;
