1: K2CO3 / ethanol / 72 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 18 h / Heating
3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, from -65 deg C to -60 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to RT, 6 h
View Scheme
参考文献
Gilligan; Cain; Christos; Cook; Drummond; Johnson; Kergaye; McElroy; Rohrbach; Schmidt; Tam
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4344 - 4361
Peterson, Quinn P.; Hsu, Danny C.; Goode, David R.; Novotny, Chris J.; Totten, Ryan K.; Hergenrother, Paul J.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 18 p. 5721 - 5731